2-Amino-6-methoxy-3-nitropyridine → 2,3-Diamino-6-methoxypyridine

HRID 493597

反応式

HRID 493597 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1>CO.C(O)C>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1

参加物

3

反応物 1

HCID 38524282-Amino-6-methoxy-3-nitropyridine

生成物 1

HCID 30239202,3-Diamino-6-methoxypyridine

試薬・触媒・溶媒 1

HCID 18681192Ethanol, mixt. with methanol溶媒

実験手順

2-Amino-6-methoxy-3-nitropyridine (2.8 g, 16.5 mmol) was dissolved in warm 1:1 methanol/ethanol (200 mL). The solution was cooled, purged with argon, and 10% palladium on carbon was added (0.45 g). Hydrogen was introduced (1 atm) and the reaction stirred until complete. The catalyst was filtered and the solvent evaporated from the filtrate to give the title compound. MS 140 (M+1) 1H NMR (500 MHz, CDCl3) δ 6.93 (d, J=8 Hz, 1H), 6.04 (d, J=8 Hz, 1H), 4.15 (br s, 2H), 3.80 (s, 3H), 3.0 (br s, 2H).

後処理

  1. temperatureThe solution was cooled
  2. custompurged with argon, and 10% palladium on carbon
  3. additionwas added (0.45 g)
  4. additionHydrogen was introduced (1 atm)
  5. filtrationThe catalyst was filtered
  6. customthe solvent evaporated from the filtrate

出典と根拠

ORDレコード
ord-c9e79d9f53704fd4b417074d6b19b17e
出典データセット
uspto-grants-2009_05
特許番号
US07534784B2

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