1,1'-Carbonyldiimidazole → tert-Butyl 4-(1-(2,4-dimethoxybenzyl)-1,2-dihydro-2-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)piperidine-1-carboxylate

関与物質

役割	名称	HCID	仕込み量
反応物	1,1'-Carbonyldiimidazole	HCID 68263	—
反応物	Tert-butyl 4-((2-(2,4-dimethoxybenzylamino)pyridin-3-yl)methylamino)piperidine-1-carboxylate	HCID 22293293	—
溶媒	Water	HCID 962	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	tert-Butyl 4-(1-(2,4-dimethoxybenzyl)-1,2-dihydro-2-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)piperidine-1-carboxylate	HCID 22293273	—

反応条件

温度	150 °C

反応手順

Carbonyldiimidazole (0.65 g, 4.0 mmol) was added to a solution of the material from Step C in dimethylformamide (20 mL) and the reaction was heated to 150° C. After 1 d, further carbonyldiimidazole (0.65 g, 4.0 mmol) was added and the reaction heated for an additional 3 h. The reaction was diluted with water and extracted with dichloromethane, and the organic phase dried over sodium sulfate. The crude product was purified by chromatography (silica gel, 20 to 80% ethyl acetate in methylene chloride gradient elution), which gave the title compound (0.35 g). MS 483.3 (M+1).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07534784B2
出典データセット	uspto-grants-2009_05
ORD ID	ord-fb92df9cd9c042228f571e8b1f904b40
出典メモ	uspto-grants-2009_05