反応式
C[N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]3[C:14](=[O:15])[C:13](=[O:16])[NH:12][C:8]3=2)[CH2:3]1.ClC(OC(Cl)=O)C>ClCCCl>[NH:12]1[C:8]2=[C:9]3[C:4](=[CH:5][CH:6]=[C:7]2[C:14](=[O:15])[C:13]1=[O:16])[CH2:3][NH:2][CH2:11][CH2:10]3参加物
4
実験手順
To an ice cooled stirred suspension of 6,7,8,9-tetrahydro-7-methyl-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione (500 mg) in 1,2-dichloroethane (10 ml) was added α-chloroethylchloroformate (0.25 ml). The mixture was then brought to reflux for 1 hour, whereafter it was cooled to room temperature and filtered. The filtrate was evaporated, the residue dissolved in methanol (10 ml) and refluxed for 10 min. Evaporation of the solvent left the crude title compound as a solid, M.p. 270° C.
後処理
- temperatureto reflux for 1 hour, whereafter it
- filtrationfiltered
- customThe filtrate was evaporated
- dissolutionthe residue dissolved in methanol (10 ml)
- temperaturerefluxed for 10 min
- customEvaporation of the solvent
- waitleft the crude title compound as a solid, M.p. 270° C.
出典と根拠
- ORDレコード
- ord-461d95d8d5924dfa90fb02af4201c163
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05242918
関連ノート
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