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Lithium Chloride → (1,1-Dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Chloride | HCID 433294 | — |
| 反応物 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 反応物 | 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid | HCID 59699456 | — |
| 生成物 | (1,1-Dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone | HCID 16739577 | — |
反応手順
In analogy to the procedure described for the synthesis of example 1, step 3, the title compound was synthesized from 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloric salt with one equivalent of lithium chloride (example 2, step 1) and thiomorpholine-1,1-dioxide (purchased at Syntec, ref. M1201). The title product was obtained in 75% yield as white solid. MS (m/e): 420.5 (MH+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07538101B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-2a72d450256e4b5bb8a0f2c6e6d152c0 |
| 出典メモ | uspto-grants-2009_05 |