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Triethylamine → 4-(Bis(4-chlorophenyl)methyl)piperazin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4,4'-Dichlorobenzhydryl chloride | HCID 13078 | — |
| 反応物 | Piperazin-2-one | HCID 231360 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(Bis(4-chlorophenyl)methyl)piperazin-2-one | HCID 68931779 | 83.5% |
反応手順
To a solution of chlorobis(4-chlorophenyl)methane (407 mg, 1.5 mmol) in MeCN was added piperazin-2-one (601 mg, 6.0 mmol) followed by triethylamine (626 μl, 4.5 mmol) and the resulting mixture was refluxed overnight. After cooling to rt, the solvent was evaporated to dryness and the residue was submitted to column chromatography (SiO2, DCM to DCM/MeOH=100:5) to give 4-(bis(4-chlorophenyl)methyl)piperazin-2-one (420 mg) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07538114B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-27f77bb0ef1241de99bd80c85f018621 |
| 出典メモ | uspto-grants-2009_05 |