Cyclohexanone → Methyl 3-cyclohexyl-1H-indole-6-carboxylate

反応式

N1C2C(=CC=C(C(O)=O)C=2)C=[CH:2]1.C1(=O)CCCCC1.[C:20]1([C:26]2[C:34]3[C:29](=[CH:30][C:31]([C:35]([OH:37])=[O:36])=[CH:32][CH:33]=3)[NH:28][CH:27]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH:21]=1>>[CH:20]1([C:26]2[C:34]3[C:29](=[CH:30][C:31]([C:35]([O:37][CH3:2])=[O:36])=[CH:32][CH:33]=3)[NH:28][CH:27]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

参加物

反応物 3

HCID 7967Cyclohexanone

HCID 5952301H-indole-6-carboxylic acid

HCID 111840773-(Cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid

生成物 1

HCID 11230631Methyl 3-cyclohexyl-1H-indole-6-carboxylate

実験手順

Condensation of 1H-indole-6-carboxylic acid with cyclohexanone can generate 3-cyclohexenyl-1H-indole-6-carboxylic acid. This indole ester can be subjected to sequential reduction and esterification to provide methyl 3-cyclohexanyl-1H-indole-6-carboxylate.

出典と根拠

ORDレコード: ord-e2206595e90141d6b4c1cf0313823007
出典データセット: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07538102B2

反応ノート

読み込み中…