Ethylamine → (CH3)3Coc(O)nhch2C(O)nhch2CH3

HRID 494121ノート

反応式

HRID 494121 の反応式
[CH2:1]([NH2:3])[CH3:2].CO[C:6](=[O:16])[CH2:7][NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>>[C:12]([O:11][C:9]([NH:8][CH2:7][C:6]([NH:3][CH2:1][CH3:2])=[O:16])=[O:10])([CH3:13])([CH3:14])[CH3:15]

参加物

3

反応物 2

HCID 6341EthylamineHCID 637609N-Boc-glycine methyl ester

生成物 1

HCID 57248348(CH3)3Coc(O)nhch2C(O)nhch2CH3

実験手順

Ethylamine (37 g, 0.82 mol) was condensed into a pressure vessel at 0° C. N-(tert-butoxycarbonyl)glycine methyl ester (50 mL, 0.34 mol) was added. The vessel was sealed and the mixture was stirred at room temperature overnight. The product mixture was concentrated under vacuum and the residue was passed through a pad of silica gel eluting with ethyl acetate. The solution was concentrated under vacuum to provide the title compound as a clear oil.

後処理

  1. customcondensed into a pressure vessel at 0° C
  2. customThe vessel was sealed
  3. concentrationThe product mixture was concentrated under vacuum
  4. concentrationThe solution was concentrated under vacuum

出典と根拠

ORDレコード
ord-b7f176b77d0a48b7bec71e30620c4bd3
出典データセット
uspto-grants-2009_05
特許番号
US07538112B2

反応ノート

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