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7-Aminoquinoline → 9-Oxo-9H-fluorene-2-carboxylic acid quinolin-7-yl amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Aminoquinoline | HCID 11377 | — |
| 反応物 | Fluorenone-2-carboxylic acid | HCID 69913 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 9-Oxo-9H-fluorene-2-carboxylic acid quinolin-7-yl amide | HCID 57682673 | — |
反応手順
To a solution of 7-aminoquinoline (D55) (35 mg, 0.24 mmol) in DCM (3 ml) was added 9-oxo-9H-fluorene-2-carboxylic acid (60 mg, 0.27 mmol), (3-dimethylamino-propyl)-ethyl-carbodiimide hydrochloride (68 mg, 0.36 mmol) and 4-dimethylaminopyridine (5 mg, 0.04 mmol) and the reaction stirred at room temperature then at reflux until complete by tlc. After cooling to room temperature the resultant precipitate was filtered off to give the title compound as an off-white solid. MS(ES): MH+ 351, M-H+ 349
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07538121B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-e46a805cfcff40e3a1a945274cb69073 |
| 出典メモ | uspto-grants-2009_05 |