3,4-Difluorobenzeneboronic acid → 6-(3,4-Difluorophenyl)-N-quinolin-7-yl-nicotinamide

HRID 494267

反応式

HRID 494267 の反応式
Cl[C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[O:7])=[CH:4][N:3]=1.[F:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][C:27]=1[F:28]>>[F:21][C:22]1[CH:23]=[C:24]([C:2]2[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]3[CH:18]=[C:17]4[C:12]([CH:13]=[CH:14][CH:15]=[N:16]4)=[CH:11][CH:10]=3)=[O:7])=[CH:4][N:3]=2)[CH:25]=[CH:26][C:27]=1[F:28]

参加物

3

反応物 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 445789876-Chloro-N-quinolin-7-yl-nicotinamide

生成物 1

HCID 576827156-(3,4-Difluorophenyl)-N-quinolin-7-yl-nicotinamide

実験手順

Using the procedure outlined in Example 100, the title compound was prepared from 6-chloro-N-quinolin-7-yl-nicotinamide (D70) (40 mg, 0.14 mmol) and 3,4-difluorophenylboronic acid (27 mg, 0.17 mmol) as a cream solid. 1H NMR (250 MHz, CDCl3) δ (ppm): 9.24 (dd, 1H), 8.86 (dd, 1H), 8.39 (dd, 1H), 8.28 (dd, 1H), 8.14 (br.d, 1H), 8.13 (d, 1H), 7.97 (ddd, 1H), 7.85 (m, 3H), 7.39 (dd, 1H), 7.28 (m, 1H).

出典と根拠

ORDレコード
ord-ff038ccf114d402aaac273ab265213de
出典データセット
uspto-grants-2009_05
特許番号
US07538121B2

関連ノート

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