Hydrochloric Acid → HCID 57682666、化合物

HRID 494294ノート

反応式

HRID 494294 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][N:9]2C(=O)C(F)(F)F)=[CH:4][CH:3]=1.[CH3:18][C:19]1[N:27]=[C:26]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[C:30]([F:35])[CH:29]=2)[CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22].Cl>>[F:35][C:30]1[CH:29]=[C:28]([C:26]2[CH:25]=[CH:24][C:20]([C:21]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH2:6][CH2:7][CH2:8][NH:9]4)=[CH:4][CH:3]=3)=[O:22])=[C:19]([CH3:18])[N:27]=2)[CH:33]=[CH:32][C:31]=1[F:34]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 690380912-Methyl-6-(3,4-difluorophenyl)nicotinic acidHCID 820484221-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone

生成物 1

HCID 57682666HCID 57682666、化合物

実験手順

Using the procedure outlined in Example 38, the title compound was prepared from 7-amino-1-trifluoroacetyl-1,2,3,4-tetrahydroquinoline (D5) (73 mg, 0.30 mmol) and 2-methyl-6-(3,4-difluorophenyl)nicotinic acid (D108) (82 mg, 0.33 mmol) then converted to the HCl salt as a buff solid. 1H NMR (400 MHz, DMSO) δ (ppm): 8.23 (dd, 1H), 8.04 (m, 3H), 7.87 (d, 1H), 7.63 (d, 1H), 7.57 (m, 1H), 7.29 (d, 1H), 3.34 (m, 2H), 2.80 (m, 2H), 2.67 (s, 3H), 2.02 (m, 2H).

出典と根拠

ORDレコード
ord-4abc59f5ba0f4b5baba4d153fbaa52ee
出典データセット
uspto-grants-2009_05
特許番号
US07538121B2

反応ノート

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