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Hydrochloric Acid → HCID 178418666、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triethylamine hydrochloride | HCID 11130 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 4-Benzyloxybenzonitrile | HCID 561371 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 178418666 | HCID 178418666 | 98.1% |
反応手順
A mixture of 285 g of the nitrile, 262.5 g triethylamine hydrochloride and 124 g of sodium azide in 1.5 L of DMF under nitrogen was stirred under reflux for 18 hrs. The reaction mixture was cooled to room temperature, poured into 4 L of cold water and acidified with 3N HCl. The resulting white solid was collected, washed with water and dried at 60° C. in vacuo for 48 hrs to give 337 g of 5-(4-benzyloxyphenyl)tetrazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242924 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-da4ba2e333534753ac71b51a2ea124e5 |
| 出典メモ | uspto-grants-1993_09 |