2-[bis(methylsulfanyl)methylene]-4,4-dibutyl-1,3(2H,4H)-naphthalenedione → Tert-butyl 3-(7-fluoro-1-hydroxy-3-oxo-4,4-dipropyl-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4h-1,2,4-benzothiadiazin-7-ylcarbamate

HRID 494481ノート

反応式

HRID 494481 の反応式
CS[C:3](SC)=[C:4]1[C:13](=[O:14])[C:12]([CH2:18][CH2:19][CH3:20])([CH2:15][CH2:16][CH3:17])[C:11]2[C:6](=[CH:7][C:8]([F:21])=[CH:9][CH:10]=2)[C:5]1=[O:22].CSC(SC)=C1C(=O)C(CCCC)(CCCC)C2C(=CC=CC=2)C1=O.[NH2:50][C:51]1[CH:56]=[CH:55][C:54]([NH:57][C:58](=[O:64])[O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[CH:53][C:52]=1[S:65]([NH2:68])(=[O:67])=[O:66].NC1C=CC(OCC2C=CC=CC=2)=CC=1S(N)(=O)=O>>[F:21][C:8]1[CH:7]=[C:6]2[C:11]([C:12]([CH2:15][CH2:16][CH3:17])([CH2:18][CH2:19][CH3:20])[C:13](=[O:14])[C:4]([C:3]3[NH:50][C:51]4[CH:56]=[CH:55][C:54]([NH:57][C:58](=[O:64])[O:59][C:60]([CH3:62])([CH3:63])[CH3:61])=[CH:53][C:52]=4[S:65](=[O:66])(=[O:67])[N:68]=3)=[C:5]2[OH:22])=[CH:10][CH:9]=1

参加物

5

反応物 4

HCID 112111042-[bis(methylsulfanyl)methylene]-4,4-dibutyl-1,3(2H,4H)-naphthalenedioneHCID 114854142-[Bis(methylthio)methylene]-7-fluoro-4,4-dipropylnaphthalene-1,3(2h,4h)-dioneHCID 59805694(4-Amino-3-sulfamoyl-phenyl)-carbamic acid tert-butyl esterHCID 670639862-Amino-5-(benzyloxy)benzenesulfonamide

生成物 1

HCID 136384912Tert-butyl 3-(7-fluoro-1-hydroxy-3-oxo-4,4-dipropyl-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4h-1,2,4-benzothiadiazin-7-ylcarbamate

実験手順

The title compound was prepared according to the procedure of Example 5D, substituting the compound of Example 14H for the compound of Example 5C, and the compound of Example 17A for the compound of Example 2D. 1H NMR (300 MHz, DMSO-d6): δ 0.62 (m, 8 H) 0.91 (m, 2 H) 1.47 (d, J=17.28 Hz, 9 H) 1.93 (m, 2 H) 2.10 (m, 2 H) 7.63 (m, 5 H) 8.03 (s, 1 H) 9.77 (s, 1 H) 14.21 (s, 1 H).

出典と根拠

ORDレコード
ord-0fecbf78c43348eaa1bce668290cdcfa
出典データセット
uspto-grants-2009_05
特許番号
US07538105B2

反応ノート

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