Methyl 2-phenyl-2-propylpentanoate → 2-(4-Fluorophenyl)-2,5-dimethylhexanoic acid

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:18])([CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.C1(C(CCC)(CCC)C(OC)=O)C=CC=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:18])([CH2:13][CH2:14][CH:15]([CH3:16])[CH3:17])[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

参加物

反応物 2

HCID 11658708Methyl 2-phenyl-2-propylpentanoate

HCID 68872679Methyl 2-(4-fluorophenyl)-2,5-dimethylhexanoate

生成物 1

HCID 688699802-(4-Fluorophenyl)-2,5-dimethylhexanoic acid

実験手順

The title compound was prepared according to the procedure of Example 1C, substituting the compound of Example 22B for the compound of Example 1B. 1H NMR (300 MHz, CDCl3): δ 0.86 (t, J=6.43 Hz, 6 H) 1.05 (m, 2 H) 1.51 (m, 4 H) 1.96 (m, 2 H) 7.02 (m, 2 H) 7.34 (m, 2 H).

出典と根拠

ORDレコード: ord-2a168cabdfa8437baeffe0a8050076b3
出典データセット: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07538105B2

反応ノート

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