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3,5-Dimethyl-4-hydroxybenzonitrile → Win 58768
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dimethyl-4-hydroxybenzonitrile | HCID 20176 | — |
| 反応物 | Win 58768 | HCID 148372 | — |
| 反応物 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 反応物 | 6-n-Propyl-3-(4-hydroxy-1-piperidinyl)pyridazine | HCID 19797304 | — |
| 生成物 | Win 58768 | HCID 148372 | — |
| 生成物 | (3,5-dimethyl-4-hydroxyphenyl)-2H-tetrazole | HCID 86747187 | — |
反応手順
2-Methyl-5-((3,5-dimethyl-4-hydroxyphenyl)-2H-tetrazole (Formula III: R2 =R3 =R4 =CH3) was prepared according to the procedure of Example 1b starting with 2,6-dimethyl-4-cyanophenol. 4.5 Mmol of 6-methyl-3-(4-hydroxyl-1-piperidinyl)pyridazine (Formula IV: R1 =methyl, Y=CH2), 1.14 g DEAD, 6.8 mmol TPP, 5 mmol of 2-methyl-5-(3,5-dimethyl-4-hydroxyphenyl)-2H-tetrazole (Formula III: R2 =R3 =R4 =CH3) were reacted as described in Example 1c. Recrystallization from ethyl acetate afforded a 71.9% yield of the compound of Formula I (R1 =R2 =R3 =R4 =methyl, Y=CH2) m.p. 183°-184° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242924 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-497fa056f7bb46efa7e51c283e600987 |
| 出典メモ | uspto-grants-1993_09 |