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Hydrochloric Acid → Ethyl 2-(piperidin-4-yl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl pyridine-4-acetate | HCID 736321 | — |
| 触媒 | Platinum oxide (PtO) | HCID 82844 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | HCID 178418361 | HCID 178418361 | — |
| 生成物 | Ethyl 2-(piperidin-4-yl)acetate | HCID 2760465 | 162.3% |
反応手順
16.5 g (0.1 mol) Ethyl 4-pyridylacetate, 8.4 mL (0.1 mol) 12N hydrochloric acid and 2.5 g platinum oxide were dissolved in absolute ethanol and hydrogenated at 40 psi hydrogen on a Parr shaker. After 1 hour, the contents of the vessel were filtered and concentrated in vacuo yielding 27.79 g of ethyl 4-piperidinylacetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242924 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-4bf57d14da074ba286dc99dcf47db4ab |
| 出典メモ | uspto-grants-1993_09 |