N-methyl-1-(1-benzyloxycarbonylpiperidin-4-yl)-1H-indole-6-carboxamide → 1-(piperidin-4-yl)-N-methyl-1H-indole-6-carboxamide

HRID 494915ノート

反応式

HRID 494915 の反応式
[CH3:1][NH:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][N:11]2[CH:14]2[CH2:19][CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15]2)=[CH:7][CH:6]=1)=[O:4].[H][H]>CO.[C].[Pd]>[CH3:1][NH:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][N:11]2[CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)=[O:4]

参加物

5

反応物 2

HCID 57682860N-methyl-1-(1-benzyloxycarbonylpiperidin-4-yl)-1H-indole-6-carboxamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 576828371-(piperidin-4-yl)-N-methyl-1H-indole-6-carboxamide収率 83.6%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒2 回HCID 887Methanol溶媒

実験手順

1.77 g of N-methyl-1-(1-benzyloxycarbonylpiperidin-4-yl)-1H-indole-6-carboxamide was dissolved in 30 ml of methanol. Then, 200 mg of 10% palladium carbon was added to the obtained solution. The reaction atmosphere was replaced by hydrogen, and it was then stirred at room temperature. After completion of the reaction, 10% palladium carbon was filtered off from the reaction solution, and the reaction solution was then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate/methanol), followed by solidification from a mixed solution consisting of ethyl acetate, t-butylmethyl ether, and methanol, so as to obtain 973 mg of the subject compound.

後処理

  1. customThe reaction atmosphere
  2. filtrationwas filtered off from the reaction solution
  3. concentrationthe reaction solution was then concentrated under a reduced pressure
  4. customThe residue was purified by NH silica gel column chromatography (ethyl acetate/methanol)

出典と根拠

ORDレコード
ord-300aff1a8c3347148e59f89c6d1fa17c
出典データセット
uspto-grants-2009_05
特許番号
US07538123B2

反応ノート

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