6-Methoxy-7-(2-methoxyvinyl)quinoline → (6-Methoxyquinolin-7-yl)acetaldehyde

HRID 494968ノート

反応式

HRID 494968 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH:13]=[CH:14][O:15]C)[N:9]=[CH:8][CH:7]=[CH:6]2>Cl.O1CCCC1.C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH2:13][CH:14]=[O:15])[N:9]=[CH:8][CH:7]=[CH:6]2

参加物

4

反応物 1

HCID 688560946-Methoxy-7-(2-methoxyvinyl)quinoline

生成物 1

HCID 57682887(6-Methoxyquinolin-7-yl)acetaldehyde収率 110%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 18422008HCl tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

1.41 g of 6-methoxy-7-(2-methoxyvinyl)quinoline was dissolved in 40 ml of 2 N hydrochloric acid-tetrahydrofuran (1:1), and the obtained mixture was then stirred at 70° C. for 2 hours. The reaction solution was cooled to a room temperature. It was diluted with ethyl acetate and then washed with a saturated sodium bicarbonate aqueous solution and a saturated sodium chloride aqueous solution. The organic layer was dried over magnesium sulfate and then concentrated under a reduced pressure, so as to obtain 1.45 g of (6-methoxyquinolin-7-yl)acetaldehyde containing triphenylphosphine oxide. This compound was used in the following reaction without further purification.

後処理

  1. temperatureThe reaction solution was cooled to a room temperature
  2. washwashed with a saturated sodium bicarbonate aqueous solution
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated under a reduced pressure

出典と根拠

ORDレコード
ord-d1df36b1c4154fa78c2805b98af415f7
出典データセット
uspto-grants-2009_05
特許番号
US07538123B2

反応ノート

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