Acetone → DN9H25S82Z

HRID 495009ノート

反応式

HRID 495009 の反応式
[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:35])([CH3:34])[O:10]2)=[CH:5][CH:4]=1.[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].CC(C)=O>O>[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:34])([CH3:35])[O:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 180AcetoneHCID 444972Fumaric AcidHCID 11677552E-2110 free base

生成物 1

HCID 16038980DN9H25S82Z収率 88.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (1.00 g) and fumaric acid (0.249 g) were dissolved in a mixed solvent consisting of acetone (5 ml) and water (15 ml) at 60° C. Thereafter, the obtained mixture was left at room temperature for 1 hour. The deposited solid was collected by filtration, and the obtained product was then washed with a mixed solvent consisting of acetone (2.5 ml) and water (7.5 ml), so as to obtain the subject compound (1.09 g).

後処理

  1. filtrationThe deposited solid was collected by filtration
  2. washthe obtained product was then washed with a mixed solvent

出典と根拠

ORDレコード
ord-1b0e6c68c95d48d08c2ce61cc609d9cf
出典データセット
uspto-grants-2009_05
特許番号
US07538123B2

反応ノート

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