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Carbon Dioxide → 2-Phenylisobutyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Dioxide | HCID 280 | — |
| 反応物 | 2-Phenylisobutyric acid | HCID 13222 | — |
| 反応物 | Neophyl chloride | HCID 68191 | — |
| 反応物 | 3,3-Dimethyl-1-indanone | HCID 304628 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 生成物 | 2-Phenylisobutyric acid | HCID 13222 | — |
| 生成物 | 2,5-Dimethyl-2,5-diphenylhexane | HCID 316705 | — |
反応手順
A convenient synthesis into 3,3-dimethyl indan-1-one is via the acid catalysed cyclisation of phenylisobutyric acid. The phenylisobutyric acid may be prepared by reaction of neophylchloride with magnesium followed by carbon dioxide under known conditions. Typically, one obtains phenylisobutyric acid in admixture with an unwanted coupling product 2,5-dimethyl-2,5-diphenyl hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07538243B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-e9d2482638e5442e8234f0af31d5e552 |
| 出典メモ | uspto-grants-2009_05 |