Formic Acid → 4-Methylbenzimidazole
反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9].Cl.[OH-].[NH4+].[CH:13](O)=O>>[CH3:9][C:3]1[C:2]2[N:1]=[CH:13][NH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1参加物
5
実験手順
To a flask were added 2.0 g 2,3-diaminotoluene, 1.0 g 90% formic acid and 30 ml 5M hydrochloric acid and the mixture was heated to 90 C under nitrogen for 4 hours. After cooling to 22 C, the mixture was basified with aqueous ammonium hydroxide and the product was removed by filtration and washed with water. The product was purified by column chromatography using pure ethyl acetate resulting in 1.0 g brown solid.
後処理
- temperaturethe mixture was heated to 90 C under nitrogen for 4 hours
- temperatureAfter cooling to 22 C
- customthe product was removed by filtration
- washwashed with water
- customThe product was purified by column chromatography
出典と根拠
- ORDレコード
- ord-bca620d033864315bf0ee9387fe50dbd
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07538931B2
反応ノート
読み込み中…