(2-Nitrophenyl)hydrazine → 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbaldehyde 2-(2-nitrophenyl)hydrazone

HRID 495395

反応式

HRID 495395 の反応式
[Cl:1][C:2]1[C:3]([CH:12]=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[N+:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:23][NH2:24])([O-:16])=[O:15]>C(O)C>[N+:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:23][N:24]=[CH:12][C:3]1[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:5][N:4]=1)([O-:16])=[O:15]

参加物

4

反応物 2

HCID 3314739(2-Nitrophenyl)hydrazineHCID 220187903-Chloro-5-(trifluoromethyl)picolinaldehyde

生成物 1

HCID 686150543-Chloro-5-(trifluoromethyl)-2-pyridinecarbaldehyde 2-(2-nitrophenyl)hydrazone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3-chloro-5-(trifluoromethyl)pyridine-2-carboxaldehyde (1.05 g) and 2-nitrophenylhydrazine (0.76 g) in ethanol (75 ml) was heated at reflux for 2.5 hours and then allowed to cool to room temperature overnight. The resulting orange solid was isolated by filtration and recrystallised (petrol) to afford the title compound as admixture of isomers, m.p. 127-35° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 hours
  3. customThe resulting orange solid was isolated by filtration
  4. customrecrystallised (petrol)

出典と根拠

ORDレコード
ord-35658f78fa5c461cbe8d5acfc759eb93
出典データセット
uspto-grants-2005_09
特許番号
US06939882B1

関連ノート

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