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4-Chlorobutyryl chloride → 1,4-Benzodioxan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobutyryl chloride | HCID 78370 | — |
| 反応物 | Ethyl indole-5-carboxylate | HCID 10987040 | — |
| 反応物 | 3-(4-Aminobutyl)-5-ethoxycarbonylindole | HCID 19797347 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1,4-Benzodioxan | HCID 10301 | — |
| 生成物 | 3-(4-Chlorobutyl)-5-ethoxycarbonylindole | HCID 19438863 | — |
| 生成物 | 3(4-Phthalimidobutyl)-5-ethoxycarbonylindole | HCID 19797343 | — |
反応手順
A mixture of 2.18 g of 3-(4-aminobutyl)-5-ethoxycarbonylindole [obtainable from 5-ethoxycarbonylindole by reaction with 4-chlorobutyryl chloride, reduction of the product to give 3-(4-chlorobutyl)-5-ethoxycarbonylindole and conversion into 3(4-phthalimidobutyl)-5-ethoxycarbonylindole] and one equivalent of 6-N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane ("B") in 40 ml of acetone and 40 ml of water is boiled for 24 hours and worked up in the conventional manner. 6-[4-(4-(5-ethoxycarbonylindol-3-yl)butyl)piperazino]-1,4-benzodioxane is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242925 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-cd278516758a47cb98650ef6509a3367 |
| 出典メモ | uspto-grants-1993_09 |