Sulfuric Acid → 1-Isoquinolinyloxyacetaldehyde
反応式
C[O:2][C:3](OC)([O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][N:7]=1)[CH3:4].O1CCOCC1.S(=O)(=O)(O)O>O>[C:6]1([O:5][C:3](=[O:2])[CH3:4])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][N:7]=1参加物
5
反応条件
- 温度
- 85 °C
実験手順
A mixture of 1-isoquinolinyloxyacetaldehyde dimethyl acetal (0.93 g, 4 mmol), dioxane (10 mL), water (15 mL) and conc. sulfuric acid (2 mmol) was heated at 85° C. for 2 h, then was quenched with saturated aqueous sodium hydrogen carbonate (100 mL). The resulting mixture was extracted with dichloromethane (2×100 mL) and the combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate (50 mL), dried over sodium sulfate and evaporated in vacuo to give the title compound (0.43 g, 57%).
後処理
- customwas quenched with saturated aqueous sodium hydrogen carbonate (100 mL)
- extractionThe resulting mixture was extracted with dichloromethane (2×100 mL)
- washthe combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate (50 mL)
- dry with materialdried over sodium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-c65813df7712480da7f56b4b9f71f2eb
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06939871B2
反応ノート
読み込み中…