Hydrochloric Acid → 3-Bromophenyl isocyanate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl.[C:10](OCC)(=[O:12])C>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([N:5]=[C:10]=[O:12])[CH:6]=[CH:7][CH:8]=1参加物
5
実験手順
3-Bromoaniline (2.63 g, 15.3 mmol) was dissolved in ethyl acetate (100 ml) and 1N dry hydrogen chloride in diethyl ether (15.3 ml) was added and the solvents were removed in vacuo. The residue was stripped twice with toluene and the residue was suspended in toluene (30 ml). Diphosgene (6.1 ml) was added and the mixture was refluxed for 1.5 hour. After cooling, the solution was concentrated in vacuo to afford 2.63 g (87%) 3-bromophenyliso-cyanate.
後処理
- customthe solvents were removed in vacuo
- additionDiphosgene (6.1 ml) was added
- temperaturethe mixture was refluxed for 1.5 hour
- temperatureAfter cooling
- concentrationthe solution was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-6e7461da49db41cc9a495add858cf3e5
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06706744B2
反応ノート
読み込み中…