Hydrochloric Acid → 3-Bromophenyl isocyanate

HRID 49550

反応式

HRID 49550 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl.[C:10](OCC)(=[O:12])C>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([N:5]=[C:10]=[O:12])[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 115623-Bromoaniline

生成物 1

HCID 1410013-Bromophenyl isocyanate収率 87%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

3-Bromoaniline (2.63 g, 15.3 mmol) was dissolved in ethyl acetate (100 ml) and 1N dry hydrogen chloride in diethyl ether (15.3 ml) was added and the solvents were removed in vacuo. The residue was stripped twice with toluene and the residue was suspended in toluene (30 ml). Diphosgene (6.1 ml) was added and the mixture was refluxed for 1.5 hour. After cooling, the solution was concentrated in vacuo to afford 2.63 g (87%) 3-bromophenyliso-cyanate.

後処理

  1. customthe solvents were removed in vacuo
  2. additionDiphosgene (6.1 ml) was added
  3. temperaturethe mixture was refluxed for 1.5 hour
  4. temperatureAfter cooling
  5. concentrationthe solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-6e7461da49db41cc9a495add858cf3e5
出典データセット
uspto-grants-2004_03
特許番号
US06706744B2

関連ノート

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