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N-bromobutanimide → 2-(Bromomethyl)-1-chloro-3-methoxybenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 3-Chloro-2-methylanisole | HCID 76749 | — |
| 触媒 | Azobisisobutyronitrile | HCID 6547 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 2-(Bromomethyl)-1-chloro-3-methoxybenzene | HCID 22327443 | 72.7% |
反応手順
442 g of 2-chloro-6-methoxytoluene are dissolved in 2420 ml of carbon tetrachloride and, together with 516 g of N-bromosuccinimide, heated at reflux for 2 h while 5.8 g of AIBN are added. The solid is filtered off and washed with a small amount of carbon tetrachloride, the filtrate is concentrated, and the residue which remains is fractionated. 483 g of colorless oil are obtained (b.p. 100° C./1.4 mbar, m.p. 44-47° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06939888B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-13db7c02808443b4b1d3ed92957b86fe |
| 出典メモ | uspto-grants-2005_09 |