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HRID 49582作成日：2026年10月26日

3,5-Bis(trifluoromethyl)benzaldehyde → cis-4-(3,5-Bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2h-quinoline-1-carboxylic acid isopropyl ester

https://huagongshe.com/reaction/49582

反応式

関与物質

役割名称HCID仕込み量
反応物3,5-Bis(trifluoromethyl)benzaldehydeHCID 136247—
反応物cis-4-Amino-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2h-quinoline-1-carboxylic acid isopropyl esterHCID 69623683—
生成物cis-4-(3,5-Bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2h-quinoline-1-carboxylic acid isopropyl esterHCID 131723997—

反応手順

treating said cis-4-amino-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester first with 3,5-bis-trifluoromethyl-benzaldehyde under acidic conditions followed by a reducing agent to form cis-4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester;

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06706881B2
出典データセットuspto-grants-2004_03
ORD IDord-4255667a58b641f4b7711a7a1e159ac1
出典メモuspto-grants-2004_03