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Diethylene Glycol Monoethyl Ether → 6-[4-(4-(5-Carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-[4-(4-(5-Cyanobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797317 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-[4-(4-(5-Carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797326 | — |
反応手順
A mixture of 4.16 g of 6-[4-(4-(5-cyanobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane, 2.4 g of NaOH, 50 ml of H2O and 40 ml of diethylene glycol monoethyl ether is stirred at a bath temperature of 140° for 3 hours. The mixture is then cooled to room temperature, worked up in the conventional manner and gives 6-[4-(4-(5-carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242925 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-a782508ad5da4e58a935bed7bb6cedd1 |
| 出典メモ | uspto-grants-1993_09 |