関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chlorotrimethylsilane | HCID 6397 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Pyrrolidine, hydrochloride (1:1) | HCID 212848 | — |
| 反応物 | (1-Ethoxycyclopropoxy)trimethylsilane | HCID 2734686 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-(Pyrrolidin-1-yl)cyclopropanecarbonitrile | HCID 22325146 | — |
反応手順
A mixture containing a drop of trimethylsilyl chloride and 67.8 g of [(1-ethoxycyclopropyl)oxy]trimethylsilane in 65 ml of methanol is added to 62.6 g of pyrrolidine hydrochloride and 28.7 g of potassium cyanide dissolved in 260 ml of methanol. After stirring for 20 minutes at 20° C., and then for 20 hours at 50° C., the reaction mixture is concentrated to dryness, taken up in dichloromethane, filtered and concentrated to dryness again. The residue is chromatographed over silica gel (CH2Cl2) allowing the desired product to be isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06943184B2 |
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| 出典データセット | uspto-grants-2005_09 |
|---|
| ORD ID | ord-bdc44c5517794472b5931f634f1b8229 |
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| 出典メモ | uspto-grants-2005_09 |
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