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Nitrogen → 6-[4-(4-(5-Hydroxymethylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitrogen | HCID 947 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-[4-(4-(5-Methoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797327 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 6-[4-(4-(5-Hydroxymethylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797328 | — |
反応手順
A solution of 4.4 g of 6-[4-(4-(5-methoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane in 40 ml of THF is added dropwise with stirring in an N2 atmosphere at 20° to a suspension of 0.6 g of lithium aluminium hydride in 20 ml of THF. The mixture is stirred at 20° for 1 hour, decomposed with dilute sodium hydroxide solution and filtered, and the filtrate is worked up in the conventional manner and gives 6-[4-(4-(5-hydroxymethylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242925 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-22a8f936264443019aa427698e2e3d90 |
| 出典メモ | uspto-grants-1993_09 |