2-Ethyl-2-((2-Hydroxymethylphenyl)thiomethyl)hexenal → 2-Ethyl-2-((2-formylphenyl)thiomethyl)hexenal

HRID 496164ノート

反応式

HRID 496164 の反応式
[CH2:1]([C:3]([CH2:10][S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][OH:19])([CH:6]=[CH:7][CH2:8][CH3:9])[CH:4]=[O:5])[CH3:2].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH2:1]([C:3]([CH2:10][S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH:18]=[O:19])([CH:6]=[CH:7][CH2:8][CH3:9])[CH:4]=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 544309312-Ethyl-2-((2-Hydroxymethylphenyl)thiomethyl)hexenalHCID 178418287HCID 178418287、化合物

生成物 1

HCID 537561052-Ethyl-2-((2-formylphenyl)thiomethyl)hexenal収率 66%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3.7 g of 16, 5.6 g (0.026 mole) of pyridinium chlorochromate, 2 g of Celite and 30 mL of methylene chloride was stirred for 18 h and filtered through a bed of silica gel. The silica gel was eluted with methylene chloride. The combined methylene chloride eluant was purified by HPLC (20% ETOAc-hexane) to give 2.4 g (66%) of an oil.

後処理

  1. filtrationfiltered through a bed of silica gel
  2. washThe silica gel was eluted with methylene chloride
  3. customThe combined methylene chloride eluant was purified by HPLC (20% ETOAc-hexane)

出典と根拠

ORDレコード
ord-db4d46dca8914dc9a04939c34825e336
出典データセット
uspto-grants-2005_09
特許番号
US06943189B2

反応ノート

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