関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Nitro-m-cresol | HCID 12788 | — |
| 触媒 | Epibromohydrin | HCID 18430 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Oxirane, ((5-methyl-2-nitrophenoxy)methyl)- | HCID 153034 | 83% |
反応手順
A mixture of 5-Methyl-2-nitrophenol (7.7 g, 50 mmol), potassium carbonate (13.8 g, 0.1 mmol) and epibromohydrine (8.25 mL, 0.1 mmol) was dissolved in DMF (100 mL) and stirred 2-3 h at 100° C. under an atmosphere of nitrogen. The mixture was diluted with ether (0.5L) and extracted with water until pH=7. The organic phase was evaporated and the residue was purified by flash-chromatography on silica (DCM) to give the sub-title compound as a yellow solid (8.65 g, 83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06943188B2 |
|---|
| 出典データセット | uspto-grants-2005_09 |
|---|
| ORD ID | ord-fb52fea343044fd4b0211f5acc6755f7 |
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| 出典メモ | uspto-grants-2005_09 |
|---|
