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Hydrochloric Acid → (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Bromoacetonitrile | HCID 11534 | — |
| 反応物 | 4-(Naphth-1-yl)piperidine hydrobromide | HCID 19096220 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride | HCID 19784336 | 91.83% |
反応手順
5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242933 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-c23b7acaed9b4fbbb249c32c51607fe4 |
| 出典メモ | uspto-grants-1993_09 |