Hydrochloric Acid → 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride
反応式
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:22]>CO>[ClH:22].[N:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:17][CH:18]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine (25 g, 85.8 mmol) was dissolved in methanol (100 mL) and was cooled to 0° C. Saturated HCl in methanol (100 mL) was added, and the mixture allowed to warm to room temperature for 1 h. The mixture was concentrated under vacuum and provided 1-[2-(4-pyridinyl)ethyl]piperazine hydrochloride (23.8 g, 92%) as a white solid.
後処理
- temperatureto warm to room temperature for 1 h
- concentrationThe mixture was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-9c493352f063490796c1719b4e4490e3
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06946467B2
反応ノート
読み込み中…