関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Butyl bromide | HCID 8002 | — |
| 反応物 | 3-Aminobenzyl alcohol | HCID 80293 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | [3-(Butylamino)phenyl]methanol | HCID 22322603 | — |
反応手順
To a solution of 3.69 g (30 mmol) of 3-amino benzyl alcohol in 20 ml DMSO was added 3.78 g (45 mmol) solid NaHCO3 and 2.91 ml (27 mmol) 1-bromobutane. The reaction was allowed to stir at 50° C. for 18 hours (overnight). Reaction was worked up by adding 250 ml water and product was extracted in ethyl acetate. Water was added, and the resultant mixture was extracted with EtOAc. The organic layer was washed with water and brine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06946481B1 |
|---|
| 出典データセット | uspto-grants-2005_09 |
|---|
| ORD ID | ord-09101997df5349ed8a295f2fba2bb391 |
|---|
| 出典メモ | uspto-grants-2005_09 |
|---|
