化工社化工社 化学情報印刷レポート · 研究参考用
Hydrocodone → Codeine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrocodone | HCID 5284569 | — |
| 反応物 | Thebaine | HCID 5324289 | — |
| 反応物 | Codeinone | HCID 5459910 | — |
| 生成物 | Codeine | HCID 5284371 | — |
| 生成物 | Thebaine | HCID 5324289 | — |
| 生成物 | Codeinone | HCID 5459910 | — |
反応手順
Hydrocodone has been prepared by reduction of codeinone (Arch. Pharm (1920), 258, 295; J. Am Chem. Soc (1950), 72, 3247, U.S. Pat. No. 5,571,685) or thebaine (DE Pat. No. 441,613). However, since codeinone is obtained by oxidation of codeine in low to moderate yields, and thebaine is a relatively scarce alkaloid, these methods have little practical value.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06946556B1 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-c46228bdbd2a46d990394e87ee0a0f24 |
| 出典メモ | uspto-grants-2005_09 |