3-Cyclohexyl-2-dimethoxymethylacrylonitrile → 2-Cyano-3-cyclohexylpropenal

HRID 496822ノート

反応式

HRID 496822 の反応式
C[O:2][CH:3](OC)[C:4](=[CH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[C:5]#[N:6]>Cl>[C:5]([C:4](=[CH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH:3]=[O:2])#[N:6]

参加物

3

反応物 1

HCID 543234033-Cyclohexyl-2-dimethoxymethylacrylonitrile

生成物 1

HCID 571816332-Cyano-3-cyclohexylpropenal収率 76%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-(Dimethoxymethyl)-3-cyclohexylacrylonitrile, obtained from Example 3 (4.18 g, 0.02 mol) and 6N HCl (50 mL) were stirred together overnight at room temperature. The product was extracted with ethyl acetate (200 mL), the extract was dried) (MgSO4) and the ethyl acetate was evaporated in vacuo to give a 2.5 g (76%) of a brown oil which was used directly. A sample was distilled in a kugelrohr apparatus to give a pale yellow oil from which an analytical 2,4-dinitrophenyl hydrazone derivative was obtained as orange needles, mp 228-30° C.

後処理

  1. extractionThe product was extracted with ethyl acetate (200 mL)
  2. dry with materialthe extract was dried) (MgSO4)
  3. customthe ethyl acetate was evaporated in vacuo

出典と根拠

ORDレコード
ord-4453313c10f14955a4e9e33705d4043f
出典データセット
uspto-grants-2005_09
特許番号
US06946554B2

反応ノート

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