関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Carbamimidic acid, methyl ester, sulfate (1:1) | HCID 169039 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N,N'-dibenzoylcarbamimidoic acid, methyl ester | HCID 69749939 | — |
反応手順
O-Methylisourea hydrogen sulfate (17.2 g, 0.1 mol) was suspended in water (100 mL) containing NaOH (20 g, 0.5 mol) and the mixture cooled to 5-10° C. The mixture was stirred vigorously as benzoyl chloride (35.15 g, 0.25 mol) was added at such a rate that the reaction temperature did not rise above 15° C. After the last addition, the mixture was stirred for 3 h and the resulting solid collected by vacuum filtration to give N,N′-dibenzoylcarbamimidoic acid, methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06946554B2 |
|---|
| 出典データセット | uspto-grants-2005_09 |
|---|
| ORD ID | ord-cb9abf06b9da49438ab90561af0414ed |
|---|
| 出典メモ | uspto-grants-2005_09 |
|---|
