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1-Methylimidazole → Dimethyl erucyl phosphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylimidazole | HCID 1390 | — |
| 反応物 | Phosphorochloridic acid, dimethyl ester | HCID 101863 | — |
| 反応物 | Erucyl alcohol | HCID 5354168 | — |
| 反応物 | Dimethyl erucyl phosphate | HCID 86619244 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Dimethyl phosphate anion | HCID 3753418 | — |
| 生成物 | Dimethyl erucyl phosphate | HCID 86619244 | 89% |
反応手順
Dimethyl erucyl phosphate (Compound 70) To a solution of erucyl alcohol (0.50 g, 1.5 mmol) in dry CH2Cl2 (10 mL) was added N-methylimidazole (0.14 mL, 1.7 mmol) followed by the addition of dimethyl chlorophosphate (0.20 mL, 1.9 mmol). After 20 hours, the reaction mixture was concentrated and subjected to silica-gel column chromatography [eluent: hexane/ethyl acetate, 66/33, v/v] to give dimethyl phosphate Compound 70 (0.59 g, 89%) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949528B1 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-f63ca7fff0c04821a3c9365f8c6e383b |
| 出典メモ | uspto-grants-2005_09 |