Water → 2-Acetamido-5-bromopyridine

HRID 49719

反応式

HRID 49719 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1.O>C(O)(=O)C>[Br:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:5](=[O:7])[CH3:6])=[N:10][CH:11]=1

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 706222-Amino-5-bromopyridine

生成物 1

HCID 2930972-Acetamido-5-bromopyridine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Acetic anhydride (27.4 mL) was added to a stirred suspension of 2-amino-5-bromopyridine (10.0 g) in acetic acid (40 mL). The mixture was heated at reflux for 4 hours, then cooled to room temperature and then poured into water (200 mL). The resulting solid was collected, washed three times with water (300 ml) and then dried in vacuo at 70° C., affording the title compound as a white solid (10.9 g).

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe resulting solid was collected
  4. washwashed three times with water (300 ml)
  5. customdried in vacuo at 70° C.

出典と根拠

ORDレコード
ord-a8376e32560e4ae2b4a581d3d9db980c
出典データセット
uspto-grants-2004_03
特許番号
US06706738B2

関連ノート

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