1,4-Diacetylbenzene → 1-(4-Acetylphenyl)-2-bromo-1-ethanone

HRID 497213ノート

反応式

HRID 497213 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:13]Br>C(OCC)C.O.[Cl-].[Al+3].[Cl-].[Cl-]>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH2:2][Br:13])=[CH:5][CH:6]=1)(=[O:12])[CH3:11]

参加物

6

反応物 2

HCID 138881,4-DiacetylbenzeneHCID 24408Bromine

生成物 1

HCID 149132991-(4-Acetylphenyl)-2-bromo-1-ethanone収率 88.8%

試薬・触媒・溶媒 3

HCID 6451240Aluminum(III) Chloride触媒HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a stirred solution of 1,4-diacetylbenzene (5.3 g, 32.7 mmol), aluminum chloride (0.05 g, 0.38 mmol) in diethylether (50 ml) was added bromine (5.3 g, 32.7 mmol) dropwise over 20 minutes. The mixture was stirred for 30 minutes, and diluted with water. The whole was concentrated to remove diethylether, and the aqueous suspension was filtered to give 7.0 g of white solid. The compound was used for next reaction without purification.

後処理

  1. concentrationThe whole was concentrated
  2. customto remove diethylether
  3. filtrationthe aqueous suspension was filtered

出典と根拠

ORDレコード
ord-51c10d8c02a449f0b3274ef84328c10f
出典データセット
uspto-grants-2005_09
特許番号
US06949536B2

反応ノート

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