Alpha-Cyano-4-Hydroxycinnamic Acid → HCID 178429059、化合物

HRID 49729

反応式

HRID 49729 の反応式
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([O:18][S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[S:28]([N:31]([CH2:38][C:39]([O:41]CC)=[O:40])[CH2:32][C:33]([O:35]CC)=[O:34])(=[O:30])=[O:29])(=[O:21])=[O:20])[CH:6]=[C:7]([CH:17]=1)[O:8][CH2:9][CH2:10][CH2:11][O:12][NH:13][C:14]([NH2:16])=[NH:15].C(C(=CC1C=CC(O)=CC=1)C(O)=O)#N>>[CH3:2][C:3]1[CH:4]=[C:5]([O:18][S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[S:28]([N:31]([CH2:32][C:33]([OH:35])=[O:34])[CH2:38][C:39]([OH:41])=[O:40])(=[O:30])=[O:29])(=[O:20])=[O:21])[CH:6]=[C:7]([CH:17]=1)[O:8][CH2:9][CH2:10][CH2:11][O:12][NH:13][C:14]([NH2:16])=[NH:15]

参加物

3

反応物 2

HCID 2102Alpha-Cyano-4-Hydroxycinnamic AcidHCID 1784727383-[5-methyl-3-(2-(N,N-bis(ethoxycarbonylmethyl)aminosulfonyl)phenylsulfonyloxy)phenoxy]propoxy guanidine hydrochloride

生成物 1

HCID 178429059HCID 178429059、化合物収率 87%

実験手順

The title compound was prepared in 87% yield from 3-[5-methyl-3-(2-(N,N-bis(ethoxycarbonylmethyl)aminosulfonyl)phenylsulfonyloxy)phenoxy]propoxyguanidine hydrochloride, as prepared in step b of Example 57, in a manner analogous to Example 27. 1H-NMR (300 MHz, DMSO-d6) δ 8.29 (d, J=7.0 Hz, 1H), 8.10 (d, J=7.6 Hz, 1H), 7.97 (t, J=7.6 Hz, 1H), 7.84 (t, J=7.6 Hz, 1H), 7.63 (br s, 4H), 6.72 (s, 1H), 6.58 (s, 1H), 6.49 (s, 1H), 4.13 (s, 4H), 3.97 (t, J=6.3 Hz, 2H), 3.90 (t, J=6.3 Hz, 2H), 2.23 (s, 3H), 2.03 (pentet, J=6.2 Hz, 2H). Mass spectrum (MALDI-TOF, α-cyano-4-hydroxycinnamic acid matrix) calcd. for C21H26N4O11S2: 575.1 (M+H), 597.1 (M+Na), 613.1 (M+K). Found: 575.1, 597.0, 613.1.

後処理

  1. customas prepared in step b of Example 57, in a manner analogous to Example 27

出典と根拠

ORDレコード
ord-6956c3e455ef40bc8543bae1679d01da
出典データセット
uspto-grants-2004_03
特許番号
US06706765B2

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