化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 3-iodobenzoate → Methyl 3-ethylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-iodobenzoate | HCID 69258 | — |
| 反応物 | Tributylvinyltin | HCID 81998 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl 3-ethylbenzoate | HCID 12430992 | — |
反応手順
Methyl 3-iodobenzoate (13 g) and vinyl tributyltin (20 g) were dissolved in toluene (100 ml) and tetrakis(triphenylphosphine)palladium (0) (500 mg) added. The solution was heated at reflux with stirring under N2 for 1 day. Potassium fluoride (3 g) in water (50 ml) was added and the reaction mixture was allowed to stir under N2 for 15 minutes. The product was taken up in ethyl acetate and washed with water and then brine (×2). The organic extract was dried (MgSO4) and evaporated in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242930 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-2bbab0f4ae63457f992a8d6c141b0c62 |
| 出典メモ | uspto-grants-1993_09 |