Hydrochloric Acid → (2S,3S)-2-Amino-3-methyl-1-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-pentan-1-one Hydrochloride
反応式
C(OC(=O)[NH:7][C@H:8]([C:13]([N:15]1[CH2:19][C:18]([F:21])([F:20])[C:17]([F:23])([F:22])[CH2:16]1)=[O:14])[C@@H:9]([CH3:12])[CH2:10][CH3:11])(C)(C)C.[ClH:25]>C(OCC)(=O)C>[ClH:25].[NH2:7][C@@H:8]([C@@H:9]([CH3:12])[CH2:10][CH3:11])[C:13]([N:15]1[CH2:19][C:18]([F:20])([F:21])[C:17]([F:23])([F:22])[CH2:16]1)=[O:14]参加物
4
実験手順
[(1S, 2S)-2-Methyl-1-(3,3,4,4-tetrafluoro-pyrrolidine-1-carbonyl)-butyl]-carbamic acid tert-butyl ester (200 mg, 0.56 mmol) was dissolved in ethyl acetate (4 mL), cooled to ° C. and treated with gaseous HCl for about 1 minute. After 15 minute at 0° C. and 30 minute at room temperature, the mixture was concentrated to dryness and the solid was triturated with hexane, collected and dried under vacuum overnight (124 mg, 76%, mp>250° C.).