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Hydrochloric Acid → (S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | tert-Butoxycarbonyl-L-isoleucine | HCID 2724762 | — |
| 反応物 | 3,3-Difluoroazetidine hydrochloride | HCID 2758247 | — |
| 生成物 | (S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride | HCID 69713143 | — |
反応手順
(S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride was prepared by coupling 3,3-difluoro-azetidine hydrochloride (WO 0047582) with Boc-(L)-isoleucine followed by HCl deprotection as analogously described in Example 1 (mp 195° C. dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710040B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-8454b09149134b8bb6599e0436bd96ab |
| 出典メモ | uspto-grants-2004_03 |