関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Sulfate | HCID 24436 | — |
| 反応物 | 2-(Diphenylhydroxymethyl)-1-azabicyclo[2.2.1]heptan-3-one | HCID 19797427 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Diphenylhydroxymethyl)-1-azabicyclo[2.2.1]heptan-3-ol | HCID 19797461 | — |
反応手順
2-(Diphenylhydroxymethyl)-1-azabicyclo[2.2.1]heptan-3-one (210 mg) was dissolved in THF (5 ml) at -78° C. under argon. Lithium aluminium hydride (3 ml, 1.0M in ether) was added and the mixture stirred at -78° C. for 30 min, and then warmed to room temperature whereupon the reaction mixture became homogeneous. Water (0.1 ml) was added followed by sodium hydroxide (0.35 ml, 3N) and water (0.35 ml) affording a granular precipitate. Solid sodium sulphate was added, the mixture was filtered and the filtrate evaporated. The resulting diol was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05242930 |
|---|
| 出典データセット | uspto-grants-1993_09 |
|---|
| ORD ID | ord-2296a711d5b9416e8708573c01ee1a3d |
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| 出典メモ | uspto-grants-1993_09 |
|---|
