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N,N-Dimethylaniline → 7-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylaniline | HCID 949 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | HCID 178508256 | HCID 178508256 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 7-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine | HCID 11221650 | — |
反応手順
The product from example 1, step (a) (0.89 g), phosphorus oxychloride (12 ml) and N,N-dimethylaniline (1.2 ml) were heated at reflux for 2 hours. The cooled reaction mixture was poured onto ice water and stirred for 2 hours. Chromatography (SiO2, methanol/dichloromethane as eluant) gave the subtitled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949643B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-02e158189ca04e1f92f16acf9bf29cee |
| 出典メモ | uspto-grants-2005_09 |