Water → [(2-Amino-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

関与物質

反応手順

The product from example 1, step (b) (70.0 g) and (R)-1-amino-propan-2-ol (32 ml) in N-methylpyrrolidinone (600 ml) and Hunigs base (71 ml) was heated at 110° C. for 16 hours. The mixture was poured into water (5 L) and the crude product collected at by filtration. This solid was purified by recrystallisation from acetonitrile (2.5 L) to give 65 g of the subtitled compound.

情報源と証拠