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N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide → 4-fluoro-N-(piperidin-4-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide | HCID 702501 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-fluoro-N-(piperidin-4-yl)benzamide | HCID 4778226 | 97.9% |
反応手順
A mixture of N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (937 mg) and 10% palladium on carbon (50% wet, 0.2 g) in methanol (20 ml) was stirred under hydrogen atmosphere for 7.5 hours at ambient temperature. The catalyst was removed by glass filter and the solvent was removed under reduced pressure. After rinse with diisopropyl ether, N-(piperidin-4-yl)-4-fluorobenzamide (653 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710043B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-86d50f487be049008b0004230cdd7116 |
| 出典メモ | uspto-grants-2004_03 |