N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide → 4-fluoro-N-(piperidin-4-yl)benzamide

HRID 49775

反応式

HRID 49775 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:12][CH2:13]1

参加物

4

反応物 1

HCID 702501N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide

生成物 1

HCID 47782264-fluoro-N-(piperidin-4-yl)benzamide収率 97.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (937 mg) and 10% palladium on carbon (50% wet, 0.2 g) in methanol (20 ml) was stirred under hydrogen atmosphere for 7.5 hours at ambient temperature. The catalyst was removed by glass filter and the solvent was removed under reduced pressure. After rinse with diisopropyl ether, N-(piperidin-4-yl)-4-fluorobenzamide (653 mg) was obtained.

後処理

  1. customThe catalyst was removed by glass
  2. filtrationfilter
  3. customthe solvent was removed under reduced pressure
  4. washAfter rinse with diisopropyl ether

出典と根拠

ORDレコード
ord-86d50f487be049008b0004230cdd7116
出典データセット
uspto-grants-2004_03
特許番号
US06710043B1

関連ノート

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