化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluorophenyl isocyanate → 1-Acetyl-4-(4-fluorophenylcarbamoyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| 反応物 | 1-Acetylpiperazine | HCID 83795 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-Acetyl-4-(4-fluorophenylcarbamoyl)piperazine | HCID 9860094 | 112.6% |
反応手順
To a stirred solution of 1-acetylpiperazine (0.648 g) in tetrahydrofuran (10 ml) was added 4-fluorophenyl isocyanate (0.574 g) at ambient temperature. After stirring at ambient temperature for 1 hour, the solvent was removed by evaporation under reduced pressure, and the residue was triturated with diisopropyl ether to give 1-acetyl-4-(4-fluorophenylcarbamoyl)piperazine (1.25 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710043B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-f7241cc2bca64ba49d3504aa3103dea6 |
| 出典メモ | uspto-grants-2004_03 |